Cardiac Differentiation of Human Pluripotent Stem Cells Using Defined Extracellular Matrix Proteins Reveals Essential Role of Fibronectin
Jianhua Zhang, Zachery R. Gregorich, Ran Tao, Gina C. Kim, Pratik A Lalit, Juliana Lott Carvalho, Yogananda Shamamandri Markandeya, Deane F. Mosher, Sean P. Palecek, Timothy J. Kamp
This study shows that fibronectin promotes cardiac differentiation of human pluripotent stem cells, while laminins inhibit it, and identifies fibronectin's role in early differentiation through integrin signaling.
eLife · Jun 7, 2022Peer-reviewedDevelopmental Biology