Author

Deane F. Mosher

University of Wisconsin–MadisonORCID 0000-0002-1233-1005Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:microscopy & imaging analysis· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Joshua M. MitchelliD· 2 shared C.A. BingmaniD· 1 shared Elizabeth WrightiD· 1 shared Gina C. Kim· 1 shared Jianhua ZhangiD· 1 shared Jie E YangiD· 1 shared Juliana Lott CarvalhoiD· 1 shared Pratik A Lalit· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Joshua M. MitchellORCID

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3 papers

Recent·Most cited

Substance matters: IL5 and IL33 activation of eosinophils on periostin and fibrinogen induce cytoskeletal reorganization and cell death

Joshua M. Mitchell, Deane F. Mosher

This study compares how IL5 and IL33 activate eosinophils on fibrinogen and periostin, showing distinct morphological and viability changes.

bioRxiv · Mar 2, 2026 · PreprintCell Biology

In situ crystalline structure of the Eosinophil major basic protein-1

Jie E Yang, Joshua M. Mitchell, C.A. Bingman, Deane F. Mosher, Elizabeth Wright

This study determines the in-situ crystalline structure of MBP-1 in eosinophil secretory granules and shows activation-dependent crystal expansion and extrusion.

bioRxiv · Oct 9, 2024 · PreprintBiophysics

Cardiac Differentiation of Human Pluripotent Stem Cells Using Defined Extracellular Matrix Proteins Reveals Essential Role of Fibronectin

Jianhua Zhang, Zachery R. Gregorich, Ran Tao, Gina C. Kim, Pratik A Lalit, Juliana Lott Carvalho, Yogananda Shamamandri Markandeya, Deane F. Mosher, Sean P. Palecek, Timothy J. Kamp

This study shows that fibronectin promotes cardiac differentiation of human pluripotent stem cells, while laminins inhibit it, and identifies fibronectin's role in early differentiation through integrin signaling.

eLife · Jun 7, 2022Peer-reviewedDevelopmental Biology