Ran Tao

Developmental determinants of male bias in medulloblastoma

The paper investigates sex bias in medulloblastoma by analyzing multi-omics data and mouse models, finding that testosterone drives male predominance in this tumor.

KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes

This study identifies how KBTBD4 cancer mutations drive neomorphic interactions with HDAC1/2, leading to CoREST degradation and tumor growth, and shows potential therapeutic strategies.

Cardiac Differentiation of Human Pluripotent Stem Cells Using Defined Extracellular Matrix Proteins Reveals Essential Role of Fibronectin

This study shows that fibronectin promotes cardiac differentiation of human pluripotent stem cells, while laminins inhibit it, and identifies fibronectin's role in early differentiation through integrin signaling.