Author

William Lee

Cleveland Clinic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Cancer Biology· 3 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Chris SanderiD· 3 shared Nikolaus SchultziD· 2 shared Yasin SenbabaogluiD· 2 shared Allyson McClendon· 1 shared Amrhen L. Ortega· 1 shared Anders Jacobsen· 1 shared Andre Kahles· 1 shared Andrew G Winer· 1 shared

Activity by Year

2014-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

Chris SanderORCID

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Author profile →

5 papers

Recent·Most cited

Forward genetics combined with unsupervised classifications identified zebrafish mutants affecting biliary system formation.

Divya Jyoti Singh, Kathryn M. Tuscano, Amrhen L. Ortega, Manali Dimri, Kevin Tae, William Lee, Muslim A. Muslim, Isabela Rivera Paz, Jay L. Liu, Lain X. Pierce, Allyson McClendon, Isabel Gibson, Jodi Livesay, Takuya F. Sakaguchi

The paper identifies 24 zebrafish mutants affecting biliary system formation using forward genetics and unsupervised clustering, revealing distinct genetic impacts on network structure.

Developmental Biology · May 8, 2024Peer-reviewedGenetics

Mitochondrial DNA Copy Number Variation Across Human Cancers

Ed Reznik, Martin Miller, Yasin Senbabaoglu, Nadeem Riaz, William Lee, Chris Sander

This study examines mtDNA copy number variation across 21 solid tumor types using next-generation sequencing, finding significant depletion in bladder and kidney cancers and correlations with metabolic pathway expression and specific mutations.

eLife · Feb 22, 2016Peer-reviewedGenomics

The landscape of T cell infiltration in human cancer and its association with antigen presenting gene expression

Yasin Senbabaoglu, Andrew G Winer, Ron S Gejman, Ming Liu, Augustin Luna, Irina Ostrovnaya, Nils Weinhold, William Lee, Samuel D Kaffenberger, Ying Bei Chen, Martin H Voss, Jonathan A Coleman, Paul Russo, Victor E Reuter, Timothy A Chan, , Ari Hakimi

The paper identifies clear cell renal cell carcinoma as highly infiltrated by T-cells and finds three clinically relevant clusters associated with survival outcomes.

bioRxiv · Sep 1, 2015 · PreprintCancer Biology

Integrative Genome-wide Analysis of the Determinants of RNA Splicing in Kidney Renal Clear Cell Carcinoma

Kjong-Van Lehmann, Andre Kahles, Cyriac Kandoth, William Lee, Nikolaus Schultz, Oliver Stegle, Gunnar Rätsch

The paper analyzes RNA splicing patterns in kidney renal clear cell carcinoma patients to identify tumor-specific isoforms and splicing quantitative trait loci associated with disease.

bioRxiv · Oct 19, 2014Cancer Biology

Cancer-associated recurrent mutations in RNase III domains of DICER1

Bülent Arman Aksoy, Anders Jacobsen, Robert J. Fieldhouse, William Lee, Emek Demir, Giovanni Ciriello, Nikolaus Schultz, Debora S. Marks, Chris Sander

The paper identifies recurrent DICER1 mutations in cancer that disrupt miRNA processing and cause mRNA expression imbalances, contributing to oncogenesis.

bioRxiv · Sep 12, 2014 · PreprintCancer Biology