Giovanni Ciriello

The paper investigates how different routes to whole-genome duplication (WGD) affect nuclear stability, finding that mitotic slippage uniquely causes nuclear instability.

ButterflyVI integrates statistical learning and experimental data to annotate cancer variants and discover biomarkers, finding 60% of annotated variants were previously unknown.

This study identifies two immune archetypes in HRD tumors—immune-inflamed and immune-evasive—linked to chromosomal instability and lineage, informing biomarker-driven therapies.

This study shows that SMG6-dependent NMD prevents dsRNA accumulation and immunogenicity in HCC by maintaining dsRNA homeostasis and suppressing MHC-I-presented peptides.

This study develops lymphomoids from patient lymphoma samples to assess therapy response, showing consistency with clinical outcomes.

CellCharter identifies and characterizes spatial cellular niches across diverse datasets, revealing tumor-associated neutrophil and cancer cell interactions linked to poor prognosis in lung cancer.

This study examines how HPV integration affects host chromatin structure and gene regulation in cervical cancer, finding that integrations are enriched in active chromatin regions and induce local and long-range transcriptional upregulation within TADs.

The paper uses multi-omics analysis to compare malignant and normal uveal melanocytes, identifying genomic instability and a BAP1 promoter deletion as key features of uveal melanoma.