Optimized AAV to express the unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease features in mouse models
Mei Li Díaz, Giovanni Tamburini, Diego Arriagada, Natalia Poblete, Álvaro O. Ardiles, David Neira, Denisse Sepúlveda, Gabriela Martínez, Romina Gozalvo, Javiera Arcos, Claudia Sepúlveda-Quiñenao, Els Henckaerts, Sergio Teixeira Ferreira, Adrián G. Palacios, Claudio A. Hetz
This study develops a next-generation AAV vector expressing optimized XBP1s to improve proteostasis, reducing Alzheimer's disease features in mouse models.
bioRxiv · Aug 12, 2026 · PreprintCell Biology