Álvaro O. Ardiles

This study develops a next-generation AAV vector expressing optimized XBP1s to improve proteostasis, reducing Alzheimer's disease features in mouse models.

This study examines sex-specific neurovascular and cognitive deficits in offspring of preeclampsia using a murine model, finding impaired vascular function and cognition, more severe in males and females respectively.

The paper shows that manipulating the UPR pathway can restore brain function and reduce aging-related deficits.

This study shows that Pannexin 1 ablation in adult hippocampal neurons leads to structural and functional changes, mediated by actin dynamics and Rho GTPase imbalance.

This study shows that a dynamin-2 mutation causes synaptic defects and cognitive impairments in a mouse model of centronuclear myopathy.