Discovery of an orally available potent ER aminopeptidase 1 (ERAP1) inhibitor that enhances anti-tumor responses and limits inflammatory autoimmunity in vivo.
Christopher P. Tinworth, Justyna Wojno, Michael Adam, Stephan Gade, Ashley P. Hancock, David J. Hirst, Jonathan P. Hutchinson, Semra J. Kitchen, Despoina Koumantou, Jonathan D. Lea, Stephanie Lehmann, John Liddle, Richard Lonsdale, Margarete Neu, Leng Nickels, , Efstratios Stratikos
bioRxiv · Nov 17, 2025 · PreprintImmunology