David F. Tough

This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.

The paper maps eQTLs during T cell activation and identifies immune disease risk variants that regulate gene expression dynamics, showing colocalization with disease-associated genes.

The paper generates a molecular map of human in vitro myelopoiesis from iPSC to macrophages, revealing conserved regulatory networks and new myeloid progenitors.

The paper identifies T cell states associated with immune disease variants by analyzing chromatin activity across different activation states.