The NSL complex mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise
Kin Chung Lam, Ho‐Ryun Chung, Giuseppe Semplicio, Shantanu S. Iyer, Aline Gaub, Vivek Bhardwaj, Herbert Holz, Plamen Georgiev, Asifa Akhtar
This study shows the NSL complex maintains nucleosome organization at promoters, ensuring transcription fidelity and suppressing noise by preventing nucleosome invasion into NDRs.
Genes & Development · Apr 1, 2019Peer-reviewedGenomics