Decoding EGFR ligand bias through an endocytic organelle platform
Gorana Jendrisek, D. Mesa, Stefano Freddi, Giorgia Miloro, Chiara Tordonato, Andrea Francesco Benvenuto, Micaela Quarto, Margherita Caputo, Andrea Raimondi, Giusi Caldieri, Elisa Barbieri, Simone Pelicci, Mario Faretta, Maria Grazia Malabarba, Diego Chianese, , Sara Sigismund
The paper identifies a RAC1-PLCγ2 axis that decodes EGFR ligand bias by linking receptor trafficking to metabolic programs supporting cell migration.
bioRxiv · Aug 4, 2026 · PreprintCell Biology