Successful Gene Editing of Apolipoprotein E4 to E3 in Brain of Alzheimer Model MiceAfter a Single IV Dose of Synthetic Exosome-Delivered CRISPR
Bruce Teter, Jesus J. Campagna, Chunni Zhu, Grace E. McAuley, Patricia R. Spilman, Donald B. Kohn, Varghese John
This paper demonstrates successful in vivo editing of ApoE4 to E3 in Alzheimer's model mice using synthetic exosome-delivered CRISPR, achieving low but detectable editing efficiency.
bioRxiv · Apr 23, 2024 · PreprintNeuroscience