Author

Chunni Zhu

University of California, Los Angeles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:CRISPR screen· 1

Frequent Co-Authors

Jesus J. Campagna· 3 shared Varghese JohniD· 3 shared Barbara M. JagodzinskaiD· 2 shared Dongwook Wi· 2 shared Patricia R. SpilmaniD· 2 shared Whitaker CohniD· 2 shared Bruce TeteriD· 1 shared Carolyn R. HouseriD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersNeuroscience

Jesus J. Campagna

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery of an APP-Selective BACE1 Inhibitor for Alzheimer's Disease

Jesus J. Campagna, Barbara M. Jagodzinska, Dongwook Wi, Chunni Zhu, Jessica L. Lee, Whitaker Cohn, Michael Jun, Chris Jean Elias, Samar Padder, Olivier Descamps, Clare A. Peters-Libeu, Qiang Zhang, Olivia F. Gorostiza, Karen S. Poksay, Patricia R. Spilman, , Varghese John

This paper identifies an APP-selective BACE1 inhibitor, FAH65, which shows substrate and enzyme selectivity, reduces Aβ levels, and improves cognitive performance in an AD mouse model.

Neurotherapeutics · May 20, 2025Peer-reviewedNeuroscience

Successful Gene Editing of Apolipoprotein E4 to E3 in Brain of Alzheimer Model MiceAfter a Single IV Dose of Synthetic Exosome-Delivered CRISPR

Bruce Teter, Jesus J. Campagna, Chunni Zhu, Grace E. McAuley, Patricia R. Spilman, Donald B. Kohn, Varghese John

This paper demonstrates successful in vivo editing of ApoE4 to E3 in Alzheimer's model mice using synthetic exosome-delivered CRISPR, achieving low but detectable editing efficiency.

bioRxiv · Apr 23, 2024 · PreprintNeuroscience

A therapeutic small molecule lead enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice

Xiaofei Wei, Jesus J. Campagna, Barbara M. Jagodzinska, Dongwook Wi, Whitaker Cohn, Jessica Lee, Chunni Zhu, Christine Huang, László Molnár, Carolyn R. Houser, Varghese John, István Módy

The paper identifies a small molecule that enhances gamma-oscillations and improves cognition in Alzheimer's disease model mice by modulating GABAARs.

bioRxiv · Dec 4, 2023 · PreprintNeuroscience