Author

Patricia R. Spilman

University of California, Los AngelesORCID 0000-0003-1999-1169Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

Chunni Zhu· 2 shared Jesus J. Campagna· 2 shared Varghese JohniD· 2 shared Barbara M. JagodzinskaiD· 1 shared Bruce TeteriD· 1 shared Chris Jean Elias· 1 shared Clare A. Peters-Libeu· 1 shared Dale E. BredeseniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Chunni Zhu

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2 papers

Recent·Most cited

NeuroscienceNeurotherapeuticsPeer-reviewedMay 20, 2025

Discovery of an APP-Selective BACE1 Inhibitor for Alzheimer's Disease

Jesus J. Campagna, Barbara M. Jagodzinska, Dongwook Wi…·Varghese John

This paper identifies an APP-selective BACE1 inhibitor, FAH65, which shows substrate and enzyme selectivity, reduces Aβ levels, and improves cognitive performance in an AD mouse model.

8 citations

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 23, 2024

Successful Gene Editing of Apolipoprotein E4 to E3 in Brain of Alzheimer Model MiceAfter a Single IV Dose of Synthetic Exosome-Delivered CRISPR

Bruce Teter, Jesus J. Campagna, Chunni Zhu…·Varghese John

This paper demonstrates successful in vivo editing of ApoE4 to E3 in Alzheimer's model mice using synthetic exosome-delivered CRISPR, achieving low but detectable editing efficiency.

11 citations

mouseCRISPR screen

𝕏 PostBluesky