Varghese John

Discovery of an APP-Selective BACE1 Inhibitor for Alzheimer's Disease

This paper identifies an APP-selective BACE1 inhibitor, FAH65, which shows substrate and enzyme selectivity, reduces Aβ levels, and improves cognitive performance in an AD mouse model.

Successful Gene Editing of Apolipoprotein E4 to E3 in Brain of Alzheimer Model MiceAfter a Single IV Dose of Synthetic Exosome-Delivered CRISPR

This paper demonstrates successful in vivo editing of ApoE4 to E3 in Alzheimer's model mice using synthetic exosome-delivered CRISPR, achieving low but detectable editing efficiency.

A therapeutic small molecule lead enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice

The paper identifies a small molecule that enhances gamma-oscillations and improves cognition in Alzheimer's disease model mice by modulating GABAARs.