Rapid removal of nuclear aggregates via proteasome- and VCP-dependent disaggregation
Giel Korsten, Grace P. Smith, Wilco Nijenhuis, Anne F. J. Janssen, Lukas C. Kapitein
The paper introduces nuclear PIMs to study nuclear quality control and shows that proteasome and VCP disaggregate nuclear aggregates, with subunits exported to the cytosol for aggrephagy.
bioRxiv · Jul 21, 2026 · PreprintCell Biology