Wilco Nijenhuis

This study uses volumetric bioprinting to enable post-printing optogenetic stimulation of cells within hydrogel constructs, demonstrating spatial control over light-responsive proteins and gene expression.

The paper introduces nuclear PIMs to study nuclear quality control and shows that proteasome and VCP disaggregate nuclear aggregates, with subunits exported to the cytosol for aggrephagy.

This paper introduces a miRNA feedback circuit to control synthetic receptor activity, showing tunable and autonomous regulation of synNotch receptor expression.

This paper introduces outcome-driven microscopy, combining optogenetics and smart microscopy to achieve precise control over cellular behavior through predefined outcomes.

This study uses expansion microscopy to show SARS-CoV-2 exits cells via Rab27-dependent amphisome fusion, identifying a potential therapeutic target.

The paper describes the immortalization of human nasal and bronchial airway epithelial cells using hTERT overexpression, enabling long-term genome editing studies.

This paper introduces a method to quantify intensity distribution in 3D and 2D microscopy data using spherical harmonics, demonstrating its application across various biological systems.

The paper shows Aurora B regulates abscission speed in stem cells by controlling microtubule stability through a feedback loop.