Anne F. J. Janssen

UDIST separates shape and texture in microscopy images into independent latent subspaces, enabling unbiased phenotypic analysis across biological scales.

The paper introduces nuclear PIMs to study nuclear quality control and shows that proteasome and VCP disaggregate nuclear aggregates, with subunits exported to the cytosol for aggrephagy.

A whole genome multiparametric CRISPR screen in progeria identifies new pathways that can reverse cellular aging phenotypes by targeting protein translation and related processes.

This study identifies PMLII as forming biomolecular condensates at sites of nuclear envelope disruption, suggesting a role in stabilizing the site for repair.

The paper compares lamin B and DNA levels in nuclear blebs across cell types and perturbations, finding DNA concentration is more consistently reduced than lamin B levels.

This study identifies a novel non-canonical role for CSA in maintaining nuclear envelope integrity, linking DNA repair defects to progeroid phenotypes through NE dysfunction and immune activation.