PIN1 isomerisation of BRCA1 promotes replication fork protection.
Manuel Daza-Martin, Mohammed Jamshad, Katarzyna Starowicz, Anoop Singh Chauhan, James F.J. Beesley, Jennifer L. Coles, Grant S. Stewart, Ruth M. Densham, Joanna R. Morris
This study identifies PIN1-mediated BRCA1 isomerisation as a regulator of replication fork protection through enhanced BRCA1-BARD1-RAD51 interaction, distinct from BRCA1's role in homologous recombination.
bioRxiv · Nov 28, 2018 · PreprintCell Biology