TP53 and RB1 are predictive genetic biomarkers for sensitivity to cytarabine in gliomas
Liisi Laaniste, Joachim Luginbühl, Mi K. Trinh, Rachel Watkins, Gregor Lueg, Grant W. A. Neilson, Marjolein Burgers, Kasia Kania, Regina Hertfelder Reynolds, Zoe Smith, Julia Kleniuk, Lauren A. Gould, Dorota Pregowska, Sophie Mathiesen, Michael R. Johnson, Louwai Muhammed
The paper identifies TP53 and RB1 wild-type status as predictors of cytarabine sensitivity in gliomas using CRISPRi screening and machine learning analysis.
bioRxiv · Nov 20, 2025 · PreprintCancer Biology