Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
Ali Yousefian-Jazi, Suhyun Kim, Seung-Hye Choi, Jiyeon Chu, Phuong Thi Nguyen, Uiyeol Park, Kayeong Lim, Hongik Hwang, KyungEun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, , Jung-Hee Lee
This study shows that an enhancer mutation in MEF2C causes mitochondrial dysfunction and motor deficits in mice by impairing mitochondria-encoded gene expression.
bioRxiv · Jul 15, 2024 · PreprintNeuroscience