Jung-Hee Lee

Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation

This study identifies the AXL-ICD/SIRT2 axis as a mechanism by which amyloid-β impairs astrocytic autophagy and exacerbates neuroinflammation in Alzheimer's disease.

Pharmacological intervention targeting neuroimmune axis in the aging hypothalamus prevents age-associated physiological decline

This study identifies the CCL3/4-CCR5 axis as a therapeutic target to delay aging by inhibiting T cell infiltration in the hypothalamus.

Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice

This study shows that an enhancer mutation in MEF2C causes mitochondrial dysfunction and motor deficits in mice by impairing mitochondria-encoded gene expression.

Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimers Disease

This study shows that astrocytic urea cycle detoxifies Aβ-derived ammonia but impairs memory in Alzheimer's disease, suggesting ODC1 inhibition as a potential therapeutic strategy.