Seung Jae Hyeon

This study identifies the AXL-ICD/SIRT2 axis as a mechanism by which amyloid-β impairs astrocytic autophagy and exacerbates neuroinflammation in Alzheimer's disease.

This study shows that an enhancer mutation in MEF2C causes mitochondrial dysfunction and motor deficits in mice by impairing mitochondria-encoded gene expression.

The paper demonstrates that PET/CT imaging with 11C-acetate and 18F-FDG can visualize reactive astrocyte-mediated neuronal hypometabolism in Alzheimer's disease.

This study shows that astrocytic urea cycle detoxifies Aβ-derived ammonia but impairs memory in Alzheimer's disease, suggesting ODC1 inhibition as a potential therapeutic strategy.