Thor D. Stein

This study identifies proteomic changes in CTE brains, linking proteasome and ribosome dysfunction to disease progression and clinical features.

This study identifies the CCL3/4-CCR5 axis as a therapeutic target to delay aging by inhibiting T cell infiltration in the hypothalamus.

This study finds higher SLIT2 levels in vitreous humor compared to plasma and links lower vitreous SLIT2 to worse cognitive scores in middle-aged individuals.

The paper identifies NeuID, a novel neuron-specific lncRNA downregulated in Alzheimer's disease, as a key regulator of neuronal identity and a therapeutic target.

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

This study shows that an enhancer mutation in MEF2C causes mitochondrial dysfunction and motor deficits in mice by impairing mitochondria-encoded gene expression.

This study identifies genetic subtypes of Alzheimer's Disease using cell-based gene networks and polygenic risk scores, then repositions existing drugs for AD treatment.

This study shows that repetitive head impacts in young athletes cause neuronal loss and neuroinflammation before CTE pathology, with specific cellular changes linked to disease progression.

This study uses polygenic risk scores derived from brain transcriptomic profiles to explain clinical heterogeneity in Alzheimer's disease.

The paper demonstrates that PET/CT imaging with 11C-acetate and 18F-FDG can visualize reactive astrocyte-mediated neuronal hypometabolism in Alzheimer's disease.

This study identifies APOE genotype-specific methylation patterns in blood and brain linked to Alzheimer's disease and estrogen response.

The paper identifies circRNAs associated with Alzheimer's disease and related dementias through transcriptome analysis and validates their expression in neuronal precursor cells exposed to oligomeric tau.

The paper compares gene expression changes in early and late stages of chronic traumatic encephalopathy (CTE) and identifies factors influencing disease expression.

This paper identifies PPP2CB and C4B as key genes linked to Alzheimer's disease through a systems biology approach, showing their association with tau pathology and complement pathway activation.

The paper identifies differentially expressed mRNAs and microRNAs in human brain tissues associated with obesity and BMI using RNA sequencing from multiple cohorts.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

The paper identifies a co-expression network involving C4A, C4B, and HSPA2 linked to APOE ε2's protective effect against Alzheimer's disease, primarily associated with tau pathology.

The paper shows that ApoE alleles compete with mCRP for CD31 binding on brain endothelia, leading to differential AD pathology based on ApoE genotype.

This study identifies molecular and cellular changes in oligodendrocytes and astrocytes in CTE using single-nucleus RNA sequencing and histological analysis.

The paper identifies cell-type specific eQTLs associated with Alzheimer's disease in blood and brain tissue, finding shared genes and pathways relevant to AD risk.