Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo
Karen N. McFarland, Carolina Ceballos, Awilda M. Rosario, Thomas B. Ladd, Brenda D. Moore, Griffin Golde, Xue Wang, Mariet Allen, Nilüfer Ertekin‐Taner, Cory C. Funk, Max Robinson, Priyanka Baloni, Noa Rappaport, Paramita Chakrabarty, Todd Eliot Golde
The paper compares microglial transcriptomic responses to Aβ peptide aggregates ex vivo and in vivo, finding distinct responses and highlighting the limitations of using ex vivo models to predict in vivo behavior.
Life Science Alliance · Jun 14, 2021Peer-reviewedNeuroscience