Karen N. McFarland

Sex dependent effect of amyloidosis on functional network hub topology is associated with downregulated neuronal gene signatures in the APPswe/PSEN1dE9 double transgenic mouse

The paper examines how amyloidosis affects functional network hub topology and gene expression in male and female APP-PS1 mice, finding sex-dependent changes in connectivity and gene signatures.

Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

Differential age effects on functional network development link to contextual memory disruption in APOE4 versus APOE3 homozygous mice

This study examines how APOE4 and APOE3 homozygosity affect functional brain networks and contextual memory in mice across age, showing differential network development and memory disruption in APOE4 adults.

Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease

The paper identifies a conserved Aβ amyloid 'responsome' in human and mouse AD brains, showing how amyloid scaffolds proteins involved in disease pathology.

Human APOE allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse Apoe in transgenic mouse models of Alzheimer amyloidosis

This study shows human APOE variants reduce both diffuse and fibrillar Aβ deposits in transgenic mouse models compared to mouse Apoe, with APOE3 more effective than APOE4 in some contexts.

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways

This study shows that deletion of Abi3/Gngt2 affects amyloid β and tau pathologies differently with age in AD models.

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

The paper compares microglial transcriptomic responses to Aβ peptide aggregates ex vivo and in vivo, finding distinct responses and highlighting the limitations of using ex vivo models to predict in vivo behavior.