Author

Brenda D. Moore

Emory UniversityORCID 0000-0002-9685-6561Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Todd Eliot GoldeiD· 3 shared Cory C. FunkiD· 2 shared Danny Ryu· 2 shared Karen N. McFarlandiD· 2 shared Kazi Farhana AfroziD· 2 shared Max RobinsoniD· 2 shared Nicholas T. SeyfriediD· 2 shared Nilüfer Ertekin‐TaneriD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Todd Eliot GoldeORCID

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3 papers

Recent·Most cited

Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasis

Kyu Hwan Shim, Yong Ran, Danny Ryu, Brenda D. Moore, Yeeun Yook, Pooneh Amin, Xuefei Liu, Kazi Farhana Afroz, Caroline Martin, Mihir Beheray, Wangchen Tsering, Lei Liu, Madison E. Platt, Blaine Roberts, Nicholas T. Seyfried, , Todd Eliot Golde

This study shows that Syndecan-4 has both HS-dependent and HS-independent effects on Aβ amyloid homeostasis, reducing amyloid deposition in a mouse model.

bioRxiv · Aug 25, 2026 · PreprintNeuroscience

Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease

Yona Levites, Eric B. Dammer, Yong Ran, Wangchen Tsering, Duc M. Duong, Measho H. Abreha, Joshna Dharmendrabhai Gadhavi, Kiara Lolo, Jorge A. Trejo‐Lopez, Jennifer Phillips, Andrea Iturbe, Aya Erquizi, Brenda D. Moore, Danny Ryu, Aditya Natu, , Todd Eliot Golde

The paper identifies a conserved Aβ amyloid 'responsome' in human and mouse AD brains, showing how amyloid scaffolds proteins involved in disease pathology.

Cell Reports Medicine · Aug 1, 2024Peer-reviewedNeuroscience

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

Karen N. McFarland, Carolina Ceballos, Awilda M. Rosario, Thomas B. Ladd, Brenda D. Moore, Griffin Golde, Xue Wang, Mariet Allen, Nilüfer Ertekin‐Taner, Cory C. Funk, Max Robinson, Priyanka Baloni, Noa Rappaport, Paramita Chakrabarty, Todd Eliot Golde

The paper compares microglial transcriptomic responses to Aβ peptide aggregates ex vivo and in vivo, finding distinct responses and highlighting the limitations of using ex vivo models to predict in vivo behavior.

Life Science Alliance · Jun 14, 2021Peer-reviewedNeuroscience