Shear-Induced Macrophage Secretome Promotes Endothelial Permeability
Elysa Jui, Griffin Kingsley, Sarah Jimenez, Hong T. Kim Phan, George I. Ezeokeke, Fariha N. Ahmad, Ravi K. Birla, Sundeep G. Keswani, K. Jane Grande-Allen
This study shows that shear stress on macrophages increases their secretion of inflammatory factors, which in turn increases endothelial permeability and contributes to fibrosis in discrete subaortic stenosis.
bioRxiv · Jun 20, 2025 · PreprintBioengineering