Ravi K. Birla

This study shows that shear stress on macrophages increases their secretion of inflammatory factors, which in turn increases endothelial permeability and contributes to fibrosis in discrete subaortic stenosis.

This study shows that shear stress conditioning of porcine endocardial endothelial cells induces a pro-inflammatory response, mediated by CD31 and involving PI3K-AKT and TNF-a signaling pathways.

This study shows that shear stress in porcine endothelial cells releases cytokines that trigger fibrotic responses in cardiac fibroblasts, contributing to discrete subaortic stenosis.

This study identifies molecular differences in pulmonary vein stenosis (PVS) subtypes using bulk RNA sequencing, highlighting PIEZO1 overexpression and its role in aggressive PVS through extracellular matrix and calcium signaling changes.

This study develops a method to bioprint functional human Purkinje networks and compatible molds to study interactions with cardiomyocytes.

This study analyzes genomic and proteomic differences between recurrent and non-recurrent discrete subaortic stenosis patients to identify predictive markers for reoccurrence.