Kathryn Jane Grande-Allen

This study identifies syndecan-3 as a regulator of inflammation and EndMT in aortic valve endothelial cells, showing its role in suppressing NF-kappaB activation and mesenchymal transition.

This study shows that shear stress on macrophages increases their secretion of inflammatory factors, which in turn increases endothelial permeability and contributes to fibrosis in discrete subaortic stenosis.

This study shows that shear stress conditioning of porcine endocardial endothelial cells induces a pro-inflammatory response, mediated by CD31 and involving PI3K-AKT and TNF-a signaling pathways.

This study shows that shear stress in porcine endothelial cells releases cytokines that trigger fibrotic responses in cardiac fibroblasts, contributing to discrete subaortic stenosis.

This study develops a method to create aligned peptide nanofibers and shows how their alignment affects hydrogel properties and cell behavior.

This study analyzes gender and racial representation on editorial boards of biomedical engineering journals from 2016 to 2021, revealing persistent disparities despite increasing female degree-earners in the field.

This study analyzes genomic and proteomic differences between recurrent and non-recurrent discrete subaortic stenosis patients to identify predictive markers for reoccurrence.

This study identifies major sources of transcriptomic variation in human intestinal organoids, showing that culture methods like substrate and format have large effects compared to experimental manipulations.