A translational kidney organoid system bolsters human relevance of clinical development candidate
Amy D. Westerling-Bui, Thomas W. Soare, Srinivasan P Venkatachalan, Michael DeRan, Eva Maria Fast, Alyssa B. Fanelli, Sergii Kyrychenko, Hien G. Hoang, Grinal M. Corriea, Wei Zhang, Maolin Yu, Matthew H. Daniels, G. Malojcic, Xin-Ru Pan-Zhou, Mark W. Ledeboer, , Peter H. Mundel
The paper develops a high-throughput human kidney organoid platform for drug screening, validated by scRNA-Seq and showing protective effects of CsA and GFB-887 against kidney injury.
bioRxiv · Dec 30, 2019 · PreprintGenomics