Eva Maria Fast

BMP9 regulates the endothelial secretome to drive pulmonary hypertension

This study shows that inhibiting BMP9 signaling reduces endothelial secretion of vasoactive factors that drive pulmonary vascular remodeling in pulmonary hypertension.

Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomes

The paper identifies how dmPGE2 regulates inflammatory gene activation in HSPCs by modulating enhancer chromatin structure through H2A.Z-variant nucleosome retention and acetylation.

Niche signals regulate continuous transcriptional states in hematopoietic stem cells

The paper identifies six HSC states and shows niche perturbations induce rapid transitions between them, revealing HSC-specific molecular signatures and chromatin features related to regenerative potential.

A translational kidney organoid system bolsters human relevance of clinical development candidate

The paper develops a high-throughput human kidney organoid platform for drug screening, validated by scRNA-Seq and showing protective effects of CsA and GFB-887 against kidney injury.

Specific Oxylipins Enhance Vertebrate Hematopoiesis via the Receptor GPR132

The paper identifies GPR132 as a specific receptor for certain oxylipins that enhance hematopoiesis in vertebrates, using bioinformatics and functional assays.