Duaa Hassan Al-Rawi

Evolution of oncogene amplification across 86,000 cancer cell genomes

The paper analyzes the evolutionary trajectories of high-level copy-number amplifications in cancer cell genomes to distinguish between extrachromosomal and intrachromosomal amplification mechanisms.

Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA

This study tracks clonal evolution of drug resistance in ovarian cancer using structural variants in cfDNA, finding polyclonal resistance with dominant high-fitness clones and genomic features linked to drug resistance.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.