Beyond Cell Cycle Control: CDKN2A Loss Orchestrates NAD⁺ Metabolic Plasticity and NAMPT Inhibitor Sensitivity in Glioblastoma
Swati Dubey, Guanqiao Yu, Ryana Aboul-Hosn, Christopher Tse, David A. Nathanson, Albert Lai, Keith A. Vossel, Fausto J. Rodríguez
The paper shows CDKN2A loss in glioblastoma affects NAD+ metabolism and increases sensitivity to NAMPT inhibitors, beyond its role in cell cycle control.
bioRxiv · Dec 4, 2025 · PreprintCancer Biology