Predictable clonal hierarchies from restricted progenitors provide a framework for cell type-specific therapies in glioblastoma
Elisa Fazzari, Daria J. Azizad, Matthew X. Li, Weihong Ge, Shivani Baisiwala, Dimitri Cadet, Patricia R. Nano, Ryan L. Kan, Travis Perryman, Hong A. Tum, Christopher Tse, Brittney D Wick, Carolina Varona-Arguelles, Kunal S. Patel, Linda M. Liau, , Aparna Bhaduri
The paper maps clonal hierarchies in glioblastoma using lineage-resolved single-cell data, revealing multiple non-redundant progenitors and identifying cell type-specific therapeutic targets.
bioRxiv · Feb 23, 2026 · PreprintCancer Biology