Discovery of new deaminase functions by structure-based protein clustering
Jiaying Huang, Qiupeng Lin, Hongyuan Fei, Zixin He, Hu Xu, Yunjia Li, Kunli Qu, Peng Han, Qiang Gao, Boshu Li, Guanwen Liu, Lixiao Zhang, Jiacheng Hu, Rui Zhang, Erwei Zuo, , Caixia Gao
The paper uses AlphaFold2 to cluster deaminase proteins by structure, discovers new properties, and develops improved base editors for therapeutic and agricultural use.
Cell · Jun 27, 2023Peer-reviewedMolecular Biology