Directed evolution of a compact TranC11a system for efficient genome editing
Zixu Zhu, Quan Q. Gao, Qiang Gao, He Jia, Zhiwei Peter Wang, Mingyang He, Lijuan Li, Lixiao Zhang, Shengnan Li, Shuai Jin, Caixia Gao, Kevin Tianmeng Zhao
This study evolves the TranC11a system to improve genome editing efficiency in human and plant cells, achieving performance comparable to SpCas9.
bioRxiv · Sep 28, 2025 · PreprintSynthetic Biology