Kunli Qu

Discovery of new deaminase functions by structure-based protein clustering

The paper uses AlphaFold2 to cluster deaminase proteins by structure, discovers new properties, and develops improved base editors for therapeutic and agricultural use.

Cell free extrachromosomal circular DNA is common in human urine

This study identifies and characterizes over one million urinary cell free eccDNAs in healthy adults, revealing their genomic distribution, sequence features, and potential role of direct repeats in their biogenesis.

Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy

The paper introduces TRAP-seq to quantify CRISPR editing efficiency and uses it to design improved gRNAs for Cas9, ABE, and CBE with high accuracy and efficiency.