Peng Han

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

The paper uses AlphaFold2 to cluster deaminase proteins by structure, discovers new properties, and develops improved base editors for therapeutic and agricultural use.

The paper introduces TRAP-seq to quantify CRISPR editing efficiency and uses it to design improved gRNAs for Cas9, ABE, and CBE with high accuracy and efficiency.

This study examines intratumor heterogeneity and evolution patterns in colorectal cancer, finding a Darwinian pattern with differences between right-sided and left-sided tumors.