PLA2G15 is a Lysosomal BMP Hydrolase and Its Targeting Ameliorates Lysosomal Disease
Kwamina Nyame, Jian Xiong, Hisham N. Alsohybe, Arthur P.H. de Jong, Isabelle V. Peña, Ricardo de Miguel, Thijn R. Brummelkamp, Guido Hartmann, Sebastian M. B. Nijman, Matthijs Raaben, Judith Simcox, Vincent A. Blomen, Monther Abu-Remaileh
This study identifies PLA2G15 as a lysosomal BMP hydrolase and shows its targeting improves lysosomal disease symptoms in NPC1 models.
Nature · May 7, 2025Peer-reviewedCell Biology