Author

Arthur P.H. de Jong

Utrecht UniversityORCID 0000-0002-7620-2704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein design· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Harold D. MacGillavryiD· 2 shared Jelmer WillemsiD· 2 shared Eline Jasmijn MertensiD· 1 shared Frank Julius MeyeiD· 1 shared Fred de WinteriD· 1 shared Guido Hartmann· 1 shared Hisham N. AlsohybeiD· 1 shared Isabelle V. Peña· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Harold D. MacGillavryORCID

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3 papers

Recent·Most cited

PLA2G15 is a Lysosomal BMP Hydrolase and Its Targeting Ameliorates Lysosomal Disease

Kwamina Nyame, Jian Xiong, Hisham N. Alsohybe, Arthur P.H. de Jong, Isabelle V. Peña, Ricardo de Miguel, Thijn R. Brummelkamp, Guido Hartmann, Sebastian M. B. Nijman, Matthijs Raaben, Judith Simcox, Vincent A. Blomen, Monther Abu-Remaileh

This study identifies PLA2G15 as a lysosomal BMP hydrolase and shows its targeting improves lysosomal disease symptoms in NPC1 models.

Nature · May 7, 2025Peer-reviewedCell Biology

Multiplex labeling and manipulation of endogenous neuronal proteins using sequential CRISPR/Cas9 gene editing

Wouter J. Droogers, Jelmer Willems, Harold D. MacGillavry, Arthur P.H. de Jong

This paper introduces CAKE, a method for multiplex CRISPR/Cas9 gene editing in neurons to label and manipulate endogenous proteins with high accuracy and low crosstalk.

eNeuro · Jul 1, 2022Peer-reviewedNeuroscience

ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons

Jelmer Willems, Arthur P.H. de Jong, Nicky Scheefhals, Eline Jasmijn Mertens, Lisa A.E. Catsburg, Rogier B. Poorthuis, Fred de Winter, Joost Verhaagen, Frank Julius Meye, Harold D. MacGillavry

ORANGE enables targeted genomic integration of fluorescent tags in neurons to study endogenous protein distribution with high-resolution imaging.

PLoS Biology · Apr 10, 2020Peer-reviewedNeuroscience