A combinatorial approach to ALS therapies in the PrP.TDP43-315 model of ALS; complications and tribulations
Susan Fromholt, Amanda Lopez, Guilian Xu, Qing Lü, James P. Wymer, David Borchelt
The paper tests drug combinations in a TDP43-ALS mouse model to extend lifespan but finds no substantial lifespan extension despite dietary interventions.
bioRxiv · Oct 1, 2024 · PreprintNeuroscience