Thierry Lesté-Lasserre

The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

The paper identifies molecular and functional differences between suprapyramidal and infrapyramidal blades in the mouse dentate gyrus using multi-omics approaches.

This study shows low-dose ketamine increases synaptic inputs to serotonergic neurons in the dorsal raphe, boosting serotonin release and hippocampal neurogenesis, linking rapid antidepressant effects to serotonergic plasticity.

This study investigates amyloid plaque penetrability and extracellular space rheology in an AD mouse model using imaging techniques, finding heterogeneous diffusivity and dysregulated extracellular matrix around plaques.

The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.

The paper generates and characterizes a mutant mouse lacking mitochondrial-associated CB1 receptors to study their role in brain function and drug effects.

This study identifies a specific subclass of hippocampal interneurons that regulate recognition memory consolidation through CB1 receptor signaling and GABAergic inhibition.