Induction of antiviral Interferon-Stimulated Genes (ISGs) by neuronal STING promotes the resolution of pain
Manon Defaye, Amyaouch Bradaïa, Nasser S. Abdullah, Francina Agosti, Mircea Iftinca, Vanessa Soubeyre, Kristofer Svendsen, Gurveer Gill, Mélissa Cuménal, Nadine Ghéziel, J.-C. Martin, Gaëtan Poulen, Nicolas Lonjon, Florence Vachiéry-Lahaye, Luc Bauchet, , Christophe Altier
The paper shows that neuronal STING activation induces IFN-stimulated genes, which resolve inflammatory pain through KChIP1-Kv4.3 regulation.
bioRxiv · Aug 4, 2023 · PreprintNeuroscience