Luc Bauchet

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

This study identifies spinal oxytocin circuits as a conserved mechanism through which affiliative touch reduces pain and enhances well-being in mice and humans.

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

The paper demonstrates that Cav3.2 calcium channels are expressed in human DRG neurons and exhibit sex dimorphism, supporting their role in pain mechanisms.

This paper introduces a Bayesian modeling approach to capture population protein dynamics using cohort data, showing its ability to handle inter-individual variability.

This study develops a 3-compartment model to simultaneously analyze protein dynamics in blood plasma and cerebrospinal fluid, including a hidden CNS compartment, and applies it to 69 proteins from a single individual.

The paper shows that neuronal STING activation induces IFN-stimulated genes, which resolve inflammatory pain through KChIP1-Kv4.3 regulation.

The paper shows that FoxJ1+ Pax6+ Sox2+ ependymal cells persist in the human spinal cord throughout life, maintaining neurodevelopmental gene expression and structural features similar to those in mice and young humans.

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

The paper introduces a proteomics framework to map protein turnover in human cerebrospinal fluid, identifying turnover rates for nearly 200 proteins and revealing relationships between turnover and protein origin.