Gaëtan Poulen

This study identifies spinal oxytocin circuits as a conserved mechanism through which affiliative touch reduces pain and enhances well-being in mice and humans.

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

The paper identifies a novel mechanism of serum-induced hyperalgesia through the facilitation of Cav3.2 channel gating by the peptide albumin (1-26).

The paper demonstrates that Cav3.2 calcium channels are expressed in human DRG neurons and exhibit sex dimorphism, supporting their role in pain mechanisms.

The paper shows that neuronal STING activation induces IFN-stimulated genes, which resolve inflammatory pain through KChIP1-Kv4.3 regulation.

The paper shows that FoxJ1+ Pax6+ Sox2+ ependymal cells persist in the human spinal cord throughout life, maintaining neurodevelopmental gene expression and structural features similar to those in mice and young humans.

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.