Emmanuel Bourinet

This study identifies spinal oxytocin circuits as a conserved mechanism through which affiliative touch reduces pain and enhances well-being in mice and humans.

This study investigates mechanical itch hypersensitivity in Shank3 mutant mice, finding somatosensory deficits and two pathways regulating itchiness.

The paper identifies two synthetic peptides that potently and selectively modulate ASIC3 activity, showing similar effects but differing in washout kinetics.

The paper identifies a novel mechanism of serum-induced hyperalgesia through the facilitation of Cav3.2 channel gating by the peptide albumin (1-26).

The paper demonstrates that Cav3.2 calcium channels are expressed in human DRG neurons and exhibit sex dimorphism, supporting their role in pain mechanisms.

This study investigates the role of T-type calcium channel Cav3.2 in PKCγ neurons of the spinal dorsal horn during chronic pain, showing its involvement in synaptic and intrinsic activity changes but not in firing properties.

The paper shows that neuronal STING activation induces IFN-stimulated genes, which resolve inflammatory pain through KChIP1-Kv4.3 regulation.

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

This study shows that Cav3.2 T-type calcium channels in the Anterior Pretectum are critical for neuropathic pain initiation and maintenance.

This study shows that C-LTMRs in mice influence social behavior and affective touch, with their dysfunction leading to social isolation and increased excitability promoting pro-social interactions.

The paper identifies TACAN as an essential subunit of the mechanosensitive ion channel responsible for mechanical pain sensing.

The paper shows TRPV1 channels enhance opioid analgesia during inflammation by promoting beta-arrestin2 nuclear translocation, preventing receptor desensitization.