Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics electrophysiological phenotype of the A53T mutation
Philipp Hornauer, Gustavo Prack, Nadia Anastasi, Silvia Ronchi, Taehoon Kim, Christian Donner, Fiscella Michele, Karsten Michael Borgwardt, Verdon Taylor, Ravi Jagasia, Damian Roqueiro, Andreas R. Hierlemann, Manuel S. Schröter
The paper introduces DeePhys, a tool for functional phenotyping of neurons using electrophysiological data, and shows it can predict genotype and age in iPSC-derived DA neurons with the A53T SNCA mutation.
bioRxiv · Mar 31, 2022 · PreprintNeuroscience