Ravi Jagasia

Homophilic wiring principles underpin neuronal network topology in vitro

This study identifies homophilic wiring as a principle governing neuronal network topology in vitro, outperforming traditional models in explaining connectivity patterns.

An arrayed CRISPR/Cas9 screen identifies mTORC1 as a regulator of lipid droplet accumulation in APOE E3 and APOE KO iPSC-derived microglia

Characterization of Novel Human β-glucocerebrosidase Antibodies for Parkinson Disease Research

This study characterizes two novel human GCase antibodies for use in various assays to advance Parkinson disease research.

Altered TFEB subcellular localization in nigral dopaminergic neurons of subjects with prodromal, sporadic and GBA-related Parkinson's disease and Dementia with Lewy bodies

The paper examines TFEB subcellular localization in Parkinson's and Lewy body disease brains, finding altered distribution linked to disease stages and GBA variants.

Angelman syndrome patient neuron screen identifies a potent and selective clinical ASO targeting UBE3A-ATS with long lasting effect in cynomolgus monkey

The paper identifies a potent ASO targeting UBE3A-ATS in Angelman syndrome patient neurons, showing long-lasting effects in cynomolgus monkeys.

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics electrophysiological phenotype of the A53T mutation

The paper introduces DeePhys, a tool for functional phenotyping of neurons using electrophysiological data, and shows it can predict genotype and age in iPSC-derived DA neurons with the A53T SNCA mutation.