Author

Sreedhar Saseendran Kumar

ETH ZurichORCID 0000-0002-5272-6474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:electronic health records· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Andreas R. HierlemanniD· 4 shared Alessio Paolo BuccinoiD· 3 shared Manuel S. SchröteriD· 3 shared Julian BartramiD· 2 shared Taehoon KimiD· 2 shared Xiaohan XueiD· 2 shared Dexiong CheniD· 1 shared Felix FrankeiD· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Andreas R. HierlemannORCID

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4 papers

Recent·Most cited

Scalable covariance-based connectivity inference for synchronous neuronal networks

Taehoon Kim, Dexiong Chen, Philipp Hornauer, Sreedhar Saseendran Kumar, Manuel S. Schröter, Karsten Michael Borgwardt, Andreas R. Hierlemann

This paper introduces FDDC, a method for inferring connectivity in neuronal networks, showing it outperforms existing methods and reveals a negative correlation between small-worldness and network synchrony.

bioRxiv · Jun 17, 2023 · PreprintNeuroscience

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

Julian Bartram, Felix Franke, Sreedhar Saseendran Kumar, Alessio Paolo Buccino, Xiaohan Xue, Tobias Gänswein, Manuel S. Schröter, Taehoon Kim, Krishna Chaitanya Kasuba, Andreas R. Hierlemann

The paper develops an experimental platform to analyze excitatory and inhibitory synaptic inputs in neurons and finds that spiking coincides with rapid changes in the E/I ratio.

bioRxiv · Jan 6, 2023 · PreprintNeuroscience

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xiaohan Xue, Alessio Paolo Buccino, Sreedhar Saseendran Kumar, Andreas R. Hierlemann, Julian Bartram

The paper introduces a method to identify monosynaptic connections using dendritic spine Ca2+ imaging and extracellular spiking recordings, validated with simulations.

Journal of Neural Engineering · Aug 1, 2022Peer-reviewedNeuroscience

Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays

Silvia Ronchi, Alessio Paolo Buccino, Gustavo Prack, Sreedhar Saseendran Kumar, Manuel S. Schröter, Fiscella Michele, Andreas R. Hierlemann

This study uses HD-MEAs to characterize electrophysiological phenotypes of iPSC-derived neurons and assess drug effects in Parkinson's and ALS models.

Advanced Biology · Jan 14, 2021Peer-reviewedNeuroscience